My name is Joy, and I live with and care for my youngest brother, who was diagnosed with AS about 3 years ago. Lately, however, I've noticed some change in his behavior and have begun to wonder how much is the AS and how much is his personality. He seems more easily agitated, and jumps quickly to the most negative of conclusions about me. Is this normal? He is not on any medications for the AS and am not really sure if they would do any good, anyway. If you have any suggestions or advice, please feel free to email me at: [email protected] I'm frustrated and so worn-out its beyond belief! (On top of AS he is quite ill with other diseases such as diabetes, and possible lymphoma, etc). I don't know where else to turn to.